Curated Optogenetic Publication Database

Search precisely and efficiently by using the advantage of the hand-assigned publication tags that allow you to search for papers involving a specific trait, e.g. a particular optogenetic switch or a host organism.

Showing 1 - 2 of 2 results
1.

Gezielte Injektion von Effektoren durch Kontrolle der Proteindynamik.

blue iLID LOVTRAP Y. enterocolitica Cell death
BIOspektrum (Heidelb), 24 Nov 2021 DOI: 10.1007/s12268-021-1667-4 Link to full text
Abstract: The type III secretion system (T3SS) enables direct injection of bacterial effector proteins into eukaryotic cells. We found that the dynamic cytosolic interface of the system allows Yersinia enterocolitica to suppress premature secretion at low pH, ensuring rapid activation at the site of action. Exploiting this principle, we developed a light-controlled T3SS based on optogenetic interaction switches, which provides unprecedented spatiotemporal control of protein secretion and translocation.
2.

Lichtsignale für die Hefe.

blue LOV domains Review
BIOspektrum, 19 Oct 2019 DOI: 10.1007/s12268-019-0212-1 Link to full text
Abstract: Natural photoreceptors from plants and microorganisms are used for synthetic approaches to control cell behaviour. Light perception by the photoreceptor, often by a cofactor, induces a conformational change, which is transduced to the effector and regulates its activity. Synthetic combinations of photoreceptors and effectors resulted in a wealth of cellular events that are controlled by optogenetic tools. A general approach is to regulate protein abundance controlling either protein stability, protein biosynthesis or both with optogenetic tools.
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